|Beitragstitel||Change of neuropsychiatric symptomatology after novel HCV eradication treatment.|
HCV has been confirmed as both a hepatotropic and lymphotropic virus. Therefore, the detection of defective central serotoninergic and dopaminergic neurotransmission in some HCV patients with neuropsychiatric symptoms and mild or no liver disease has suggested a possible role for HCV in inducing dysfunction in selective aminergic systems [1,2,3]. The aim of this study is to present a case report of a patient with Attention Deficit Hyperactivity Disorder and heroin dependence that after the novel treatment for the HCV eradication present a change of neuropsychiatric symptomatology with the development of psychotic spectrum disorder and suicidal plan.
We present a case report and we underline the change of neuropsychiatric symptomatology with the development of psychotic spectrum disorder and intense suicidality after a HCV eradication treatment in a patient that before was affected by an ADHD and substance dependence.
We conducted a systematic literature review with the principal scientific databases (PubMed, Embase, PsychInfo) using the key terms “HCV”, “eradication”, “psychiatric disorder”, “psychosis”, “psychomotor activation” as well as “agitation”.
Discussion and conclusion
To our knowledge in the literature there are no studies that explain our case report. We know that HCV has been confirmed as both a hepatotropic and lymphotropic virus and the detection of defective central serotoninergic and dopaminergic neurotransmission si correrlated with HCV infection, as well as the possible role for HCV in inducing dysfunction in selective aminergic systems [1,2,3]. In our case report we observe a complete change in the neuropsychiatric symptomatology, in the treatment response as well as in the severity of suicidal simptomatology. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered.
 Monaco S, et al., 2015;
 Dirks M, et al., H, 2017;
 Byrnes V, et al., 2012.