|Beitragstitel||Efficacy of pregabalin in cocaine dependence: case series and literature review.|
Pregabalin (Lyrica) is used to treat neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and pain associated with fibromyalgia in adults and approved in Europe to treat generalized anxiety disorder [1,2]. Pregabalin may have potential in the treatment of some aspects of cocaine addiction . The purpose of this report is to review the efficacy of pregabalin in a sample of dependence patients. We propouse different cases and literature review.
20 inpatients with alcohol and cocaine dependence were assessed with: SCID-P for axis I diagnosis, HAM-A (Hamilton Anxiety Scale) to quantify anxiety symptoms, Barratt Impulsiveness Scale (BIS-11), Brief Psychiatric Rating Scale (BPRS) for the general psychopathology. We conducted a systematic review of the literature with the principal scientific database (PubMed, Embase, PsychInfo), using the terms “pregabalin”, “alcohol”, “cocaine”.
There are any significant different in sociodemographic characteristics of the sample (n=20), only gender differences male are more the female (p=.036). We found a significant reduction of anxiety symptoms at the HAM-A scale, in particular item 2 p=.001; item 4 p=.002; item 7 p=.001; item 13 p=.003; item 14 p=.001 and HAM-A total score (p=.003), a sifgnificant reduction of the BIS total score (p=.001). Comorbidity and clinical correlates are explained in the table.
Discussion and conclusion
In literature few studies examine different possibility of treatment that are used to treat cocaine dependence with complete or partial agonism on dopanime receptors and/or an activity on dopamine pathways (for example methilphenidate, aripiprazole, etc.) with partial positive response. In our opinion this is the first study that explain the efficacy of pregabalin treatment in a sample of cocaine dependent patients to reduce anxiety and impulsivity. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered.
 Schifano F, 2014;
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