|Beitragstitel||Dissociative amnesia due to acute alcohol intoxication during SSRIs (fluoxetine) treatment: tree case report and literature review.|
Serotonin-specific reuptake inhibitors (SSRIs) like fluoxetine are antidepressant drugs commonly used to treat a wide spectrum of mood disorders, in particular fluoxetine is used in unipolar depression, anxiety disorders, obsessive compulsive disorder, bulimia and is an option among the “serotoninergic” agents that have been evaluated for alcoholism treatment . Depersonalization and derealization symptoms sometimes compare during alcohol intoxication, and other serious consequences are due to acute alcohol intoxication like incresed impulsiveness, loss of controll and aggressiveness . The purpose of this report is to review the presence of dissociative amnesia due to acute alcohol intoxication and explain the role of SSRIs treatment (fluoxetine) in this condition. We propouse tree different case reports and literature review.
We conducted a systematic review of the literature with the principal database (PubMed, Enbase, PsychInfo) and we present tree different case reports.
The acute alcohol intoxication during fluoxetine treatment determine a dissociative amnesia cheracterized by autobiographical memory compromission, compromission of subjective reliving, memory disturbances in the form of retrograde amnesia, derealization and depersonalization symptoms. Moreover in dissociative amnesia, several serious consequences were identified like impulsiveness, loss of control and aggressiveness.
Discussion and conclusion
In literature alcohol-related blackouts are periods of amnesia that reflect the failure of the brain to record memories of what transpires while drinking . In our case reports we suppose that SSRIs treatment (fluoxetine) play a role with alcohol in significant cognitive and behavioral impairment, but also in dissociative amnesia, derealization and depersonalization, loss of controll, impulsiveness as well as aggressiveness. In particular pharmacodynamic interaction, in which alcohol enhances the effects of the medication, particularly in the central nervous system  are invoved. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered.
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