|Beitragstitel||Gynecomastia, lower extremity pain and pregalin: case report and literature review.|
Pregabalin is a potent ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system (CNS) that exhibits potent anticonvusant, analgesic, and anxiolytic activity in a range of animal models . Pregabalin is GABA agonist like gabapentin, and it's use for the treatment of several CNS disorders including epilepsy, neuropathic pain, generalized anxiety disorder and social phobia . The aim of our case report is to explain adverse events (gynecomastia and lower extremity pain) during the treatment with pregabalin.
PC, is a 45 man afferred by our clinic for alcohol dependence and generalized anxiety disorder. He has a negative history for psychiatric disorder and for other different somatic disorders. He was treated with pregabalin until 300 mg/day and he developed during the next tree weeks of teratment, gynecomastia and lower extremity pain. We present the case report and we conducted a systematic review of the literature with the principal database.
After the slowly reduction and the abruption of the treatment with pregabalin we observe a complete resolution of gynecomastia and lower extremity pain.
Discussion and conclusion
In literaure exist only a study that explain the presence of gynecomastia and lower extremity pain due to pregabalin treatment. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered.
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